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| 產地 | 美國 |
| 品牌 | MedKoo |
| 貨號 | 464560 |
| 用途 | This product is for research use only, not for human or veterinary use. |
| 包裝規(guī)格 | 1.0mg; 5.0mg; 10.0mg; 25.0mg; 50.0mg; 100.0mg; 200.0mg; 500.0mg; |
| CAS編號 | 2132411-21-1 |
| 純度 | >98%% |
| 是否進口 | 是 |
Description: QD-394 is an inducer of reactive oxygen species (ROS) production. It induces lipid peroxidation, increases in intracellular accumulation of reactive oxygen species (ROS), and decreases in the reduced glutathione (GSH) to oxidized GSH (GSSG) ratio in MIA PaCa-2 pancreatic cancer cells when used at concentrations ranging from 0.5 to 10 μM. QD-394 is cytotoxic to MIA PaCa-2, PANC-1, and BxPC-3 cancer cells (IC50s = 0.64, 0.34, and 0.9 μM, respectively). QD-394 acts synergistically with napabucasin to reduce colony formation in MIA PaCa-2 cells.
Name: QD-394
CAS#: 2132411-21-1
Chemical Formula: C19H19N5O2
Exact Mass: 349.1539
Molecular Weight: 349.394
Elemental Analysis: C, 65.32; H, 5.48; N, 20.04; O, 9.16
Synonym: QD-394; QD394 QD 394;
IUPAC/Chemical Name: 6-((4-(4-methylpiperazin-1-yl)phenyl)amino)quinazoline-5,8-dione
InChi Key: INZGOHBCPALCGM-UHFFFAOYSA-N
InChi Code: InChI=1S/C19H19N5O2/c1-23-6-8-24(9-7-23)14-4-2-13(3-5-14)22-16-10-17(25)18-15(19(16)26)11-20-12-21-18/h2-5,10-12,22H,6-9H2,1H3
SMILES Code: O=C1C=C(NC2=CC=C(C=C2)N3CCN(C)CC3)C(C4=CN=CN=C14)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
