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- 品牌：MedKoo
- 產(chǎn)地：美國
- 貨號：464110
- cas：223134-72-3
- 發(fā)布日期： 2022-07-20
- 更新日期： 2024-08-12
| 產(chǎn)地 | 美國 |
| 品牌 | MedKoo |
| 貨號 | 464110 |
| 用途 | This product is for research use only, not for human or veterinary use. |
| 包裝規(guī)格 | 1.0mg; 5.0mg; 10.0mg; 25.0mg; 50.0mg; 100.0mg; 200.0mg; 500.0mg; |
| CAS編號 | 223134-72-3 |
| 純度 | >98%% |
| 是否進口 | 是 |
Description: Flutamide-d7 is intended for use as an internal standard for the quantification of flutamide by GC- or LC-MS. Flutamide is an androgen receptor antagonist and prodrug form of 2-hydroxy flutamide. Flutamide is converted to 2-hydroxy flutamide by the cytochrome P450 (CYP) isoform CYP1A2 in human liver microsomes. It is cytotoxic to PC3 and LNCaP prostate cancer cells with IC50 values of 98.8 and 81.8 μM, respectively. Flutamide (50 mg/kg per day) reduces tumor growth in a PC-82 mouse xenograft model. Formulations containing flutamide have been used in the treatment of prostate cancer.
Name: Flutamide-d7
CAS#: 223134-72-3
Chemical Formula: C11H4D7F3N2O3
Exact Mass: 283.1161
Molecular Weight: 283.2579
Elemental Analysis: C, 46.64; H, 6.40; F, 20.12; N, 9.89; O, 16.94
Synonym: Flutamide-d7; Flutamide d7; Niftolide-d7; Niftolide d7;
IUPAC/Chemical Name: 2-(methyl-d3)-N-(4-nitro-3-(trifluoromethyl)phenyl)propanamide
InChi Key: MKXKFYHWDHIYRV-NWOXSKRJSA-N
InChi Code: InChI=1S/C11H11F3N2O3/c1-6(2)10(17)15-7-3-4-9(16(18)19)8(5-7)11(12,13)14/h3-6H,1-2H3,(H,15,17)/i1D3,2D3,6D
SMILES Code: FC(C1=C([N+]([O-])=O)C=CC(NC(C([2H])(C([2H])([2H])[2H])C([2H])([2H])[2H])=O)=C1)(F)F
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
